When a passive cooling technique is used, meaning that an insulation material is used to protect the temperature of the goods against unwanted external temperatures, the choice could be made to insulate the cardboard box individually. This means that an insulation material is placed in the inside of the cardboard box in which the temperature sensitive products as foods, pharmaceuticals, medicines or chemicals are placed. Next the insulation and the box can be closed for shipment. This type of insulating is used when the box is not opened in the cold chain and is send directly from the shipper to the end user of the products. An advantage of this way of transport and packaging is that the cold chain remains closed during the total shipment. Al the actors in the cold chain as resellers, retailers, distribution centers, transport companies etc… are handling the insulated box in a cross-dock formula meaning that they do not open the box. A disadvantage of an individual packed or insulated box is that it creates waste at the receiver, the end user of the product. That is why the ecological footprint of the insulation becomes an important issue.